Power3 Medical's Scientific Advisory Board
Ira L. Goldknopf, Ph.D.
Dr. Goldknopf began his scientific career over 30 years ago, pioneering the
field that is now known as Proteomics. More than a decade before the start of
the Human Genome Project, Dr. Goldknopf made the earliest proteomic discovery
at Baylor College of Medicine with Harris Busch, the isolation, identification,
and sequencing of a new protein from a two-dimensional gel, Protein A24. During
the course of these investigations, he discovered that protein A24 was the
first known conjugate of two very important proteins, Histone H2A, a part of
the subunit structure that packages DNA in the cell nucleus, and Ubiquitin.
Through the work of Dr. Goldknopf and many others(>9000 publications in the
ensuing years), including Drs. Avram Hershko, Aaron Ciechanover, and Alex
Varshavsky, who shared the 2000 Lasker Award for their achievements, the
Ubiquitin Conjugation System is now known to play a major role in the
management of the inventories of proteins in the cell, cell proliferation,
programmed cell death, and most if not all major regulatory functions in health
and disease at the cellular level. Now equipped with a new perspective on the
importance of commercializing products and with the benefit of a strong
management team at Power3, Dr. Goldknopf continues to push the envelope of
Proteomics through discovery of protein biomarkers and biomarker footprints for
early detection, monitoring and drug targeting in patients with breast cancer,
neurodegenerative diseases, and chemotherapeutic drug resistance. Dr. Goldknopf
has presented his recent findings at the Human Proteome Meeting and the
International Conference on Ubiquitin, Ubiquitin-Like Proteins, and Cancer in
2004. He is the author of more than 70 publications, book chapters, and
patents.
| The Dawn of
Proteomics at Harris Busch's Pharmacology Department at Baylor College of Medicine - 1973 |  |
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Ira L. Goldknopf
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